embryonic mouse motor neurons extending into a developing limb, led by the delicate frills of the growth cone

in adulthood, each muscle fiber is innervated by a single motor neuron; however, during development, multiple neurons may reach a particular fiber and consequently must compete to establish the neuromuscular junction

ultimately, many “extra” immature synapses are eliminated, maintaining the one-to-one ratio of neuron to muscle fiber

light microscopy

credit: Jonathon Clarke

embryonic mouse motor neurons extending into a developing limb, led by the delicate frills of the growth cone

in adulthood, each muscle fiber is innervated by a single motor neuron; however, during development, multiple neurons may reach a particular fiber and consequently must compete to establish the neuromuscular junction

ultimately, many “extra” immature synapses are eliminated, maintaining the one-to-one ratio of neuron to muscle fiber

light microscopy

credit: Jonathon Clarke

Notes:

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(because pluripotency is overrated)